A two-year post-doctoral position is open at Institut des Sciences de l’Evolution, Université de Montpellier, France, to study evolutionary genomics of natural sex-reversal in a mouse species.
In natural populations of the African Pygmy mouse (Mus minutoides), two types of X chromosomes co-exist, one of which (named X*) is feminizing. This induces a drastic change in the modes of transmission of sex chromosomes, which in this system can thus be either strictly female (X*), or bisexual (X and Y). We study in the lab differences of life-history traits associated with the different sexual types (XX, X*X and X*Y females, XY males), in order to understand how this new mode of transmission contributes to the evolution of sex-linked phenotypic differences and of potential antagonism over their control.
The post-doc will study the genomic aspects of this question, by analyzing various available datasets:
– Participate in the de novo assembly and annotation of the X and X* chromosomes.
– Analyse differential gene expression between sexual types from RNA-seq data.
– Analyse population genomics data.
The post-doc will work in Montpellier at Institut des Sciences de l’Evolution (with Frédéric Veyrunes and Pierre Boursot), in close collaboration with The Earlham Institute, Norwich, UK (David Thybert) and the Institut de Génétique Humaine, Montpellier (Francis Poulat).
The candidate should have strong proven skills in bioinformatics for genomic data analyses (genome and transcriptome sequences). A background in biology (molecular or evolutionary biology) would be a plus.
The candidate should preferably have defended his/her PhD no longer than 4 years before the start of the post-doc, and should preferably not have worked in Montpellier during the last two years.
Salary will be according to the rules of Université de Montpellier, up to 2200 Euros/month net, depending on experience.
Starting date: from May 2018 to October 2018 at the latest.
Deadline for application: March 12, 2018. The call may be prolonged beyond this date in case it is not fruitful.